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Viagra – PDE5 Inhibitor for Erectile Dysfunction (Rx)

Viagra (sildenafil citrate) is a phosphodiesterase type 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) in adult men. It enhances the effect of nitric oxide (NO) by inhibiting PDE5 in the corpus cavernosum, leading to increased levels of cyclic guanosine monophosphate (cGMP), smooth muscle relaxation, and augmented penile blood flow in response to sexual stimulation.buy Viagra

Sildenafil requires sexual stimulation to be effective and does not initiate an erection in the absence of arousal. It is administered orally on an as-needed basis and is one of the most established first-line pharmacologic therapies for ED.

Key Details

Active Ingredient: Sildenafil (as citrate)
Drug Class: Phosphodiesterase type 5 (PDE5) inhibitor
Indication: Erectile dysfunction in adult men
Mechanism: PDE5 inhibition → ↑ cGMP → smooth muscle relaxation → increased penile blood flow
Administration: Oral, as needed prior to sexual activity
Prescription Status: Prescription-only medicine (availability may vary by region)

Specifications

Dosage Forms: Film-coated tablets
Available Strengths: 25 mg, 50 mg, 100 mg
Recommended Starting Dose: 50 mg
Dose Range: 25–100 mg based on efficacy and tolerability
Timing: ~30–60 minutes before sexual activity (may work earlier)
Duration of Effect: Up to ~4–5 hours
Absorption: Delayed with high-fat meals
Half-Life: ~3–5 hours /

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Metabolism: Hepatic via CYP3A4 (major) and CYP2C9 (minor)
Excretion: Primarily fecal (as metabolites), some renal
Storage: Room temperature

Dosage & Administration / buy Viagra

Take once as needed, approximately 30–60 minutes before sexual activity
Do not exceed one dose per day
Adjust dose (25 mg or 100 mg) based on response and tolerability
Consider lower starting dose in elderly or with hepatic/renal impairment

Compatibility / Suitable Use

Adult men with erectile dysfunction
Patients seeking on-demand oral therapy
Use under medical supervision, especially with comorbid conditions

Contraindications

Concomitant use with nitrates (e.g., nitroglycerin)
Concomitant use with riociguat
Known hypersensitivity to sildenafil
Caution/avoid in severe cardiovascular conditions where sexual activity is inadvisable

Warnings & Precautions

Risk of hypotension, especially with vasodilators
Potential for visual disturbances (PDE6 interaction)
Rare cases of non-arteritic anterior ischemic optic neuropathy (NAION)
Risk of priapism (seek urgent care if erection >4 hours)
Use caution with alpha-blockers (dose separation/adjustment may be required)

Adverse Effects

Common: Headache, flushing, dyspepsia, nasal congestion, dizziness
Visual: Blue-tinged vision, blurred vision (transient)
Cardiovascular: Hypotension, palpitations (rare)

Drug Interactions

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): ↑ sildenafil levels
CYP3A4 inducers (e.g., rifampicin): ↓ efficacy
Nitrates/riociguat: Contraindicated (severe hypotension)
Alpha-blockers: Additive BP-lowering effect

Why Choose Viagra?

Viagra remains a first-line, evidence-based therapy for erectile dysfunction with a well-characterized safety and efficacy profile. Its on-demand dosing, predictable onset, and extensive clinical use make it a reliable option for improving erectile response when used appropriately.buy Viagra

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